Table 2.

Plasma citrulline, chromogranin A– and GLP‐2–positive cells, villus height, crypt depth, and epithelium height

Changes from baseline, adjusted means [95% CI]	0.1 mg/day	1 mg/day	10 mg/day
Plasma citrulline, µmol/L	−1.4 [−9.3 to 6.5]	15.3 [7.7‐22.9]	15.6 [8.2‐23.0]
	P = 0.695	P = 0.001	P = 0.0009
	N = 10	N = 11	N = 11
Chromogranin A–positive cells, per mm2	−11 [−38 to 15]	−23 [−54 to 9]	−31 [−51 to −11]
	P = 0.350	P = 0.132	P = 0.008
	N = 5	N = 4	N = 6
GLP‐2–positive cells, per mm2	−4 [−7 to −1]	−1 [−5 to 3]	−3 [−6 to −1]
	P = 0.010	P = 0.551	P = 0.023
	N = 5	N = 4	N = 6
Absolute villus height, µm	−59 [−332 to 214]	167 [−177 to 511]	84 [−179 to 347]
	P = 0.578	P = 0.248	P = 0.427
	N = 4	N = 3	N = 4
Relative villus height, %	−8 [−54 to 38]	38 [−20 to 96]	28 [−16 to 73]
	P = 0.642	P = 0.142	P = 0.152
	N = 4	N = 3	N = 4
Absolute crypt depth, µm	−29 [−110 to 52]	45 [−59 to 148]	99 [25‐174]
	P = 0.400	P = 0.319	P = 0.019
	N = 4	N = 3	N = 5
Relative crypt depth, %	−11 [−53 to 32]	45 [−10 to 99]	51 [12‐90]
	P = 0.551	P = 0.089	P = 0.021
	N = 4	N = 3	N = 5
Absolute epithelium height, µm	7 [−2 to 16]	1 [−11 to 14]	14 [5‐22]
	P = 0.121	P = 0.785	P = 0.005
	N = 5	N = 4	N = 6
Relative epithelium height, %	24 [−14 to 63]	5 [−45 to 55]	54 [19‐88]
	P = 0.188	P = 0.815	P = 0.007
	N = 5	N = 4	N = 6

Note: Only one biopsy per patient was included in the histology assessment.

Abbreviation: GLP‐2, glucagon‐like peptide‐2.