Table 3.

mRNA gene expressions relative to glyceraldehyde 3‐phosphate dehydrogenase of MKI67, ACTA2, CD68, SLC5A1, SLC5A2, and SLC5A5 and tight‐junction complex proteins CLDN7, CLDN15, and OCEL1

	0.1 mg/day	1 mg/day	10 mg/day
MKI67	1.4 [1.3‐1.5]	0.9 [0.1‐1]	0.7 [0.4‐1]
	P = 0.125	P = 0.125	P = 0.313
	N = 5	N = 4	N = 6
ACTA2	0.8 [0.7‐1.1]	0.4 [0.1‐1.1]	1.5 [0.3‐8.9]
	P = 0.813	P = 0.625	P = 0.688
	N = 5	N = 4	N = 6
CD68	1.0 [0.8‐1.1]	1.4 [0.2‐1.7]	1.0 [0.6‐1.6]
	P = 0.813	P = 0.875	P = 1.000
	N = 5	N = 4	N = 6
SLC5A1	1.2 [0.9‐1.3]	1.3 [0.4‐1.8]	0.6 [0.4‐1.1]
	P = 0.875	P = 0.875	P = 0.438
	N = 4	N = 4	N = 6
SLC5A2	0.4 [0.1‐1.6]	0.9 [0.2‐1.4]	1.0 [0.5‐1.1]
	P = 0.625	P = 0.875	P = 1.000
	N = 4	N = 4	N = 5
SLC5A5	1.2 [0.5‐1.8]	1.0 [0.0‐1.0]	0.7 [0.4‐0.8]
	P = 1.000	P = 0.500	P = 0.438
	N = 5	N = 3	N = 6
CLDN7	1.3 [0.8‐1.6]	1.0 [0.5‐1.3]	0.9 [0.6‐1.7]
	P = 1.000	P = 1.000	P = 1.000
	N = 5	N = 4	N = 6
CLDN15	0.9 [0.8‐1.8]	0.6 [0.3‐1.2]	1.1 [0.4‐3.8]
	P = 1.000	P = 0.625	P = 0.844
	N = 5	N = 4	N = 6
CEL1	0.9 [0.6‐1.5]	0.5 [0.2‐0.7]	1.1 [0.9‐1.5]
	P = 0.625	P = 0.125	P = 0.562
	N = 4	N = 4	N = 6

Note: Results are presented as fold changes from baseline in each treatment dose. Median and interquartile range values are shown. Test for difference is done by the Wilcoxon signed rank test.