TABLE 1.
Study and patient characteristics in individual studies
| Reference | Country | N | Population | Age, mean ± SD | Sex, males:females |
|---|---|---|---|---|---|
| Abo‐Ali et al. (2015) | Egypt | 48 | Patients with VKC recruited from the ophthalmology clinic. Patients had not received antihistamines, steroids, or cytotoxic drugs prior to study inclusion. Patients with the following comorbidities were excluded: rhinitis, asthma, food or drug allergy, autoimmune diseases, and major system/organ failure | 15 ± 7 years | 41:7 |
| Baryishak et al. (1982) | Israel | 129 | Patients with newly diagnosed VKC or fresh attack after a quiescent period of the disease | 18 were aged 4–12 years. One was aged 20 years | 14:5 |
| Bonini et al. (2000) | Italy | 195 | Patients with newly diagnosed VKC from the ophthalmology clinic | 11 ± 6 years | 144:51 |
| Bozkurt et al., (2010) | Turkey | 27 | Patients with VKC referred to a cornea unit in a university hospital | 12 ± 4 years | 26:1 |
| Bozkurt et al. (2013) | Turkey | 67 | Patients with VKC from the ophthalmology clinic | 11 ± 4 years | 53:14 |
| Chiambaretta et al. (2012) | France | 69 | Unclear | Children, further data n/a | n/a |
| De Oliveira et al. (2006) | Brazil | 20 | Randomly chosen sample of 20 patients with VKC from the ophthalmology clinic | 11 ± 5 years | 15:5 |
| Elsurer et al. (2021) | Turkey | 39 | Patients with VKC from the ophthalmology clinic | 11 ± 3 years | 25:14 |
| Erdem et al. (2011) | Turkey | 23 | Patients with VKC from the ophthalmology clinic | 11 years (range 4–17 years) | n/a |
| Gómez‐Henao et al. (2018) | Colombia | 32 | Patients with VKC from the allergology clinic | 12 ± 3 years | 24:8 |
| Inada et al. (2007) | Japan | 13 | Patients with VKC from the ophthalmology clinic | 18 ± 8 years | 10:3 |
| Inada et al. (2009) | Japan | 15 | Patients with VKC from the ophthalmology clinic. Patients in any systemic anti‐allergic treatment were excluded | 18 ± 10 years | 13:2 |
| Jongvanitpak et al. (2020) | Thailand | 20 | Patients with VKC from the paediatric allergy clinic | 8 ± 3 years | 17:3 |
| Kocabeyoglu et al. (2008) | Turkey | 10 | Patients with VKC from the ophthalmology clinic | 14 ± 5 years | 8:2 |
| Kocaturk et al. (2012) | Turkey | 38 | Patients with VKC from the ophthalmology and the paediatric clinics | 9 ± 4 years | 24:14 |
| Kosrirukvongs et al. (2001) | Thailand | 47 | Patients with VKC from the ophthalmology clinic | 10 ± 5 years | 39:8 |
| Leonardi et al. (2006) | Italy | 406 | Patients with VKC from the ophthalmology clinic. | 83% were aged <10 years | 311:95 |
| Leonardi et al. (2015) | Italy | 10 | Patients with active VKC from the ophthalmology clinic | 12 ± 4 years | 6:4 |
| Montan et al. (1999) | Sweden | 62 | Patients with VKC from the ophthalmology clinic. | Median age 6 years | 52:10 |
| Monzón et al. (2009) | Spain | 9 | Patients with VKC from the ophthalmology and allergy clinics | 8 ± 1 years | 4:5 |
| Mumcuoglu et al. (1988) | Israel | 19 | Patients with VKC seen in the ophthalmology clinic | Mean age 6 years | 18:1 |
| Naidoo et al. (2014) | South Africa | 168 | Patients with VKC seen in the ophthalmology clinic | Range 19 months to 12.5 years | 125:43 |
| Nebbioso et al. (2015) | Italy | 26 | Patients with VKC seen in the ophthalmology clinic | All defined as children without age data | 18:8 |
| Nebbioso et al. (2018) | Italy | 47 | Patients with VKC seen in the ophthalmology clinic | 9 ± 5 years | 38:9 |
| Pokharel et al. (2009) | Nepal | 34 | Patients with VKC seen in the ophthalmology clinic | 12 patients were aged 6–10 years, overall range 2–26 years | 26:12 |
| Polido et al. (2015) | Brazil | 19 | Patients with VKC from the ophthalmology and allergy clinics | 10 ± 3 years | n/a |
| Pucci et al. (2003) | Italy | 110 | Patients with VKC seen in the ophthalmology clinic | 8 ± 3 years | 81:29 |
| Samra et al. (1984) | Israel | 27 | Patients with VKC seen in the ophthalmology clinic | 20 patients were aged 0–7 years | n/a |
| Tesse et al. (2010) | Italy | 197 | Patients with VKC seen in the paediatrics, immunology, and allergology clinic | Range 5–14 years | 126:71 |
| Tomassini et al. (1994) | Italy | 31 | Patients with VKC seen in the ophthalmology clinic. | Range 4–22 years | 24:7 |
| Tuft et al. (1989) | UK | 120 | Patients with VKC seen in the ophthalmology clinic | 87 patients were aged <16 years | 96:24 |
| Villalon Garcia et al. (2015) | Spain | 30 | Patients with VKC seen in the ophthalmology clinic | Range 4–18 years | 26:4 |
| Zicari et al. (2013) | Italy | 15 | Patients with VKC seen in the paediatrics clinic | Range 6–10 years | 10:5 |
Note: Continuous data are presented in mean ± SD unless otherwise noted. The sex distribution is presented as males:females.
Abbreviations: UK, United Kingdom; USA, United States of America.