TABLE II.
Patient Characteristics and Univariate Kaplan–Meier Analysis of Overall Survival.
| Total Cohort | Local Disease Only (Clinical N0 M0) | ||
|---|---|---|---|
| Total | 389 | Total | 118 |
| Overall Survival (OS) | % | Overall Survival (OS) | % |
| 1‐Yr | 77.5 | 1‐Yr | 90.3 |
| 3‐Yr | 46.3 | 3‐Yr | 63.5 |
| 5‐Yr | 31.0 | 5‐Yr | 34.2 |
| 10‐Yr | 18.2 | 10‐Yr | — |
| Median | 32.9 Months | Median | 43.2 Months |
| Variable | N | 5‐Yr OS (%) | p value | Variable | N | 5‐YR OS (%) | p value |
|---|---|---|---|---|---|---|---|
| Total | 389 | 31.0 | Total | 118 | 34.2 | ||
| Age | <0.001 | Age | 0.002 | ||||
| 18–59 | 140 | 34.7 | 18–59 | 36 | 38.8 | ||
| 60–69 | 90 | 32.9 | 60–69 | 32 | 47.5 | ||
| 70–79 | 89 | 30.3 | 70–79 | 32 | 25.9 | ||
| 80+ | 67 | 17.1 | 80+ | 17 | 23.1 | ||
| Sex | 0.13 | Sex | 0.03 | ||||
| Male | 226 | 27.5 | Male | 69 | 28.8 | ||
| Female | 163 | 35.8 | Female | 49 | 35.4 | ||
| Race | 0.002 | Race | 0.15 | ||||
| White | 327 | 32.5 | White | 104 | 36.3 | ||
| African American | 31 | 14.5 | African American | 8 | 31.3 | ||
| Asian‐Pacific Islander | 21 | 43.9 | Asian‐Pacific Islander | 3 | 33.3 | ||
| Other | 7 | 14.3 | Other | 1 | 0 | ||
| Primary Payer | 0.11 | Primary Payer | 0.31 | ||||
| Not insured | 18 | 0 | Not insured | 2 | 0 | ||
| Private Insurance | 143 | 37.2 | Private Insurance | 46 | 46.5 | ||
| Medicaid | 23 | 42.9 | Medicaid | 8 | 62.5 | ||
| Medicare | 181 | 26.4 | Medicare | 56 | 24.5 | ||
| Other Government Insurance | 3 | 0 | Other Government Insurance | 1 | 0 | ||
| Median Income Quartile | 0.14 | Median Income Quartile | 0.92 | ||||
| <$40,227 | 61 | 23.48 | <$40,227 | 18 | 33.3 | ||
| $40,227–50,353 | 81 | 39.24 | $40,227–50,353 | 27 | 37.9 | ||
| $50,354–63,332 | 97 | 30.33 | $50,354–63,332 | 29 | 46.2 | ||
| >= $63,333 | 146 | 30.4 | >= $63,333 | 43 | 29.2 | ||
| Facility Type | 0.80 | Facility Type | 0.12 | ||||
| Community | 96 | 28.3 | Community | 29 | 28.2 | ||
| Academic/Research | 228 | 31.2 | Academic/Research | 67 | 38.6 | ||
| Integrated Network | 35 | 22.9 | Integrated Network | 12 | 13.9 | ||
| Degree of Urbanization | 0.22 | Degree of Urbanization | 0.54 | ||||
| Metropolitan | 303 | 31.7 | Metropolitan | 87 | 33.1 | ||
| Urban | 62 | 26.6 | Urban | 25 | 27.5 | ||
| Rural | 8 | 66.7 | Rural | 4 | 66.7 | ||
| Primary Site | 0.57 | Primary Site | 0.22 | ||||
| Lip Mucosa | 25 | 54 | Lip Mucosa | 12 | 65.6 | ||
| Tongue | 12 | 32.1 | Tongue | 2 | 0 | ||
| Gingiva | 129 | 28.1 | Gingiva | 32 | 27 | ||
| Floor of Mouth | 12 | 25 | Floor of Mouth | 4 | 33.3 | ||
| Hard Palate | 133 | 31.2 | Hard Palate | 44 | 32 | ||
| Buccal Mucosa | 29 | 45.1 | Buccal Mucosa | 12 | 53.6 | ||
| Vestibule | 6 | 25 | Vestibule | 1 | — | ||
| Retromolar Trigone | 8 | 37.5 | Retromolar Trigone | 3 | 66.7 | ||
| Charlson‐Deyo Score | 0.50 | Charlson‐Deyo Score | 0.84 | ||||
| 0 | 315 | 30.9 | 0 | 94 | 32.6 | ||
| 1 | 60 | 32.6 | 1 | 21 | 43.1 | ||
| 2 | 10 | 13.3 | 2 | 2 | 0 | ||
| 3+ | 4 | 50 | 3+ | 1 | — | ||
| T Stage | 0.009 | T Stage | 0.004 | ||||
| T3 | 108 | 32.9 | T3 | 68 | 44.8 | ||
| T4 | 86 | 13.4 | T4 | 36 | 10.2 | ||
| N Stage | <0.001 | ||||||
| N0 | 131 | 33 | |||||
| N1 | 74 | 15.3 | |||||
| M Stage | <0.001 | ||||||
| M0 | 194 | 29.9 | |||||
| M1 | 27 | 0 | |||||
| AJCC Stage | <0.001 | AJCC Stage | 0.003 | ||||
| III | 73 | 44.7 | III | 68 | 44.8 | ||
| IV | 124 | 11 | IV | 35 | 9.9 | ||
| Surgery | <0.001 | Surgery | 0.42 | ||||
| No | 62 | 15.2 | No | 7 | 42.9 | ||
| Yes | 326 | 34.2 | Yes | 111 | 33.7 | ||
| Radiation | 0.07 | Radiation | 0.11 | ||||
| No | 211 | 36.1 | No | 68 | 43.5 | ||
| Yes | 178 | 25.2 | Yes | 50 | 23.7 | ||
| Chemotherapy | 0.002 | Chemotherapy | 0.80 | ||||
| No | 325 | 32.4 | No | 108 | 31.9 | ||
| Yes | 51 | 23.1 | Yes | 5 | 40.0 | ||
| Immunotherapy | 0.46 | Immunotherapy | 0.73 | ||||
| No | 339 | 31.2 | No | 107 | 32.8 | ||
| Yes | 49 | 30.7 | Yes | 11 | 51.9 | ||
| Surgical Margins | 0.01 | Surgical Margins | 0.10 | ||||
| Negative | 253 | 36.6 | Negative | 94 | 33.6 | ||
| Positive | 49 | 23 | Positive | 15 | 30.5 | ||
| Lymph Node Dissection (LNY ≥ 18) | 0.02 | Lymph Node Dissection (LNY ≥ 18) (Elective) | 0.24 | ||||
| No | 272 | 33.9 | No | 85 | 37.5 | ||
| Yes | 103 | 24.2 | Yes | 30 | 21.1 | ||
| Lymph Node Dissection (LNY ≥ 1) | 0.79 | Lymph Node Dissection (LNY ≥ 1) (Elective) | 0.80 | ||||
| No | 206 | 29.7 | No | 65 | 32.7 | ||
| Yes | 175 | 32.7 | Yes | 53 | 36.6 | ||
| Occult LN involvement | 0.004 | ||||||
| No | 38 | 45.1 | |||||
| Yes | 15 | 0 | |||||
| Treatment Regimen | 0.03 | ||||||
| Surgery Alone | 54 | 42.8 | |||||
| Surgery + RT | 37 | 11.5 |
Note: Bold indicates P‐value < 0.05.
LNY = lymph node yield.