Table 2.

NK‐cell infiltration.

Intention‐to‐treat	Baseline	Follow‐up	Within‐Group change		Between‐Group difference
	Mean (SD)	Mean (SD)	Change (95% CI)	P	Difference (95% CI)	P
NK cells tumour, cells/mm2
EX	1.51 (1.86)	1.86 (1.50)	0.35 (−0.67 to 1.36)	0.489	−0.09 (−1.85 to 1.66)	0.913
CON	1.05 (1.37)	1.49 (1.17)	0.44 (−0.99 to 1.88)	0.534
NK cells healthy, cells/mm2 *
EX	2.37 (3.33)	2.24 (2.12)	−0.13 (−1.87 to 1.62)	0.884	1.75 (−1.34 to 4.84)	0.255
CON	4.15 (4.50)	2.26 (1.59)	−1.88 (−4.43 to 0.67)	0.142

Per‐protocol	Mean (SD)	Mean (SD)	Change (95% CI)	P	Difference (95% CI)	P
NK cells tumour, cells/mm2
EX	0.47 (0.48)	2.07 (1.65)	1.60 (0.59 to 2.62)	0.004	1.16 (−0.31 to 2.63)	0.114
CON	1.05 (1.37)	1.49 (1.17)	0.44 (−0.62 to 1.50)	0.396
NK cells healthy, cells/mm2 *
EX	0.62 (0.78)	1.95 (1.48)	1.33 (−0.82 to 3.48)	0.210	3.23 (0.07 to 6.38)	0.046
CON	4.15 (4.50)	2.26 (1.59)	−1.90 (−4.21 to 0.42)	0.102

Means (SDs) are based on all available data for EX and CON at baseline and follow‐up with intention‐to‐treat (EX, n = 20 and CON, n = 10) and per‐protocol (EX, n = 11, and CON, n = 10) analysis. The mean differences are estimated means from the mixed models and therefore, within‐group change may not reflect the numerical difference between baseline and follow‐up.

Bold values statistically significant at P < 0.05.

^*The analyses in healthy tissue are based on CON, n = 9 at baseline due to lack of normal tissue in core needle biopsy.