TABLE 5.

Meta‐analysis for the Rustogi modified Navy Plaque index using a random model

Rustogi modified Navy Plaque index	Number of comparisons	Comparison	Effect size			Heterogeneity		Online Appendix number
			DiffM	95% CI	p‐Value	I 2	p‐Value	Forrest plot	Funnel plot	TSA
										Number	TSA does research the RIS or not (yes/no)
Goyal et al. (2009) 55 Ayad et al. (2012) 61 2x Klukowska et al. (2012) 62 Klukowska et al. (2013) 63 Klukowska et al. (2014‐12w) 66 Klukowska et al. (2014‐6wCOL) 67 Klukowska et al. (2014‐6wPH) 68 Ccahuana‐Vasquez et al. (2015) 69 Ccahuana‐Vasquez et al. (2018) 74 Adam et al. (2020) 77 Goyal et al. (2021) 78	12	Baseline	−0.00	(−0.01; 0.00)	0.08	0%	0.81	S11A	S11B	NA	NA
		End	0.01	(0.00; 0.03)	0.02	85%	<0.00001	S11C	S11D	S11E	Yes
Goyal et al. (2009) 55 Ayad et al. (2012) 61 2x Klukowska et al. (2012) 62 Klukowska et al. (2013) 63 Klukowska et al. (2014‐12w) 66 Klukowska et al. (2014‐6wCOL) 67 Klukowska et al. (2014‐6wPH) 68 Ccahuana‐Vasquez et al. (2015) 69 Ccahuana‐Vasquez et al. (2018) 74 Lv et al. (2018) 75 2x Adam et al. (2020) 77 Goyal et al. (2021) 78	14	Difference	0.01	(0.00; 0.02)	0.01	81%	<0.00001	S11F	S11G	NA	NA

Note: p‐Values are presented in bold if p ≤ 0.05.

Abbreviations: ?, Unclear; NA, Not applicable; RIS, Required Information Size; TSA, Trial sequential analysis.