Figure 5.

Nuclear staining for TrkA, p75^NTR and BAX in groups with increasing synovitis severity (synovitis score) and with increasing fibrosis (fibrosis score). Staining was significantly increased for all three in horses with synovitis compared to healthy horses. TrkA was increased in all horses with increased fibrosis, but p75^NTR and BAX was only significantly increased in the horses with moderate to severe fibrotic changes. Bars indicate SD from mean. Asterisks indicate statistically significant difference from synovitis score 1–4 or from fibrosis score 0–1; *p < 0.05, **p < 0.01, ***p < 0.001. BAX, Bcl‐2‐Associated X protein; p75^NTR, pan‐neurotrophin receptor; TrkA, tyrosine kinase A