FIGURE 4.

Effect of 0.1% HA2k lotion on facial wrinkles. A 0.1% HA2k lotion was applied to the faces of the human subjects. Maximum depth of the biggest wrinkle in the crow's feet facial area (A) and nasolabial fold (B) measured by visual analysis. (C) Skin sagging angle measured by the Moire topography method. (D) Skin elasticity based on R2 parameter measured by a suction method. ^†Significantly different at p < 0.05, *significantly different compared with baseline at p < 0.05, mean ± SD, n = 21