TABLE 3.
Frequencies of periodontal conditions, CAD, and diabetes in individuals with different genotypes of rs1560833, rs11225395, rs800292, and rs1061170
| ABL moderate‐severe | PPD4 ≥ 17* | PPD6 ≥ 7 † | BOP > 44% | Periodontitis | CAD | Diabetes | ||
|---|---|---|---|---|---|---|---|---|
| N (%) | ||||||||
| rs1560833 | GG | 74 (31%) | 66 (27%) | 31 (13%) | 74 (30%) | 65 (28%) | 175 (70%) | 58 (24%) |
| GA | 57 (31%) | 60 (32%) | 28 (15%) | 65 (33%) | 51 (28%) | 145 (74%) | 46 (24%) | |
| AA | 10 (25%) | 9 (23%) | 5 (13%) | 11 (26%) | 8 (21%) | 24 (57%) | 10 (24%) | |
| P = 0.72 | P = 0.42 | P = 0.84 | P = 0.58 | P = 0.64 | P = 0.10 | P = 0.99 | ||
| rs11225395 | GG | 46 (31%) | 54 (36%) | 18 (12%) | 39 (25%) | 42 (28%) | 121 (77%) | 40 (26%) |
| GA | 80 (33%) | 57 (23%) | 36 (15%) | 93 (36%) | 69 (29%) | 174 (68%) | 63 (25%) | |
| AA | 15 (21%) | 24 (33%) | 10 (14%) | 18 (24%) | 13 (18%) | 49 (65%) | 11 (15%) | |
| P = 0.13 | P = 0.02 | P = 0.76 | P = 0.02 | P = 0.20 | P = 0.08 | P = 0.14 | ||
| rs800292 | GG | 83 (34%) | 70 (29%) | 38 (16%) | 73 (30%) | 72 (30%) | 178 (69%) | 62 (24%) |
| GA | 52 (29%) | 47 (26%) | 23 (13%) | 68 (38%) | 46 (26%) | 132 (71%) | 38 (21%) | |
| AA | 6 (14%) | 17 (41%) | 3 (7%) | 9 (21%) | 6 (14%) | 33 (77%) | 14 (33%) | |
| P = 0.03 | P = 0.19 | P = 0.30 | P = 0.06 | P = 0.09 | P = 0.55 | P = 0.25 | ||
| rs1061170 | TT | 45 (30%) | 53 (35%) | 19 (13%) | 42 (27%) | 40 (27%) | 106 (68%) | 43 (28%) |
| TC | 65 (30%) | 65 (30%) | 36 (16%) | 74 (32%) | 59 (27%) | 167 (73%) | 49 (22%) | |
| CC | 28 (31%) | 17 (18%) | 8 (9%) | 32 (32%) | 23 (26%) | 65 (66%) | 21 (21%) | |
| P = 0.99 | P = 0.02 | P = 0.16 | P = 0.53 | P = 0.96 | P = 0.33 | P = 0.29 | ||
Note: Chi‐squared test. Statistically significant P‐values are indicated by boldface.
Abbreviations: ABL, alveolar bone loss; BOP, bleeding on probing; CAD, coronary artery disease; PPD, probing pocket depth.
*Number of pockets with PPD 4 to 5 mm ≥ 17.
†Number of pockets with PPD ≥ 6 mm ≥ 7.