Table 3.
5-FC dosing with renal replacement therapy.
| Dialysis method | Adjustments |
|---|---|
| Automated peritoneal dialysis (APD)/continuous ambulatory peritoneal dialysis (CAPD). | Give 50 mg/kg daily in 4 divided doses. Monitor levels. |
| Intermittent hemodialysis (HD) | Dose as in GFR < 10 ml/min, given postdialysis. Monitor trough-level predialysis, and reduce postdialysis dose accordingly |
| Intermittent hemodiafiltration (HDF)/High flux. | Dose as in GFR < 10 ml/min, given postdialysis. Monitor trough-level predialysis, and reduce postdialysis dose accordingly. |
| a Continuous arteriovenous hemofiltration (CAV)/continuous venovenous hemodialysis (VVHD). | Give dose as in GFR = 10–20 ml/min and monitor blood levels, predose. |
5-FC, 5-fluorocytosine; GFR, Glomerular filtration rate.
a
The optimal dosage for patients with renal failure requiring continuous venovenous hemofiltration or continuous venovenous hemodialysis is not yet established. 15 Serum concentrations need monitoring.