Table 1.
Participant characteristics, plasma NfL levels, brain imaging measurements, and memory test scores
|
Homozygotes (HM) n = 66 |
Heterozygotes (HT) n = 165 |
Non-carriers (NC) n = 312 |
P-value | Groupwise comparisons | |
|---|---|---|---|---|---|
| Age (years) | 66.8 ± 8.3 | 68.8 ± 9.6 | 69.3 ± 8.1 | 0.10 | na |
| Education (years) | 16.0 ± 2.5 | 16.1 ± 2.1 | 16.1 ± 2.2 | 0.91 | na |
| Sex (M/F) | 16/50 | 46/119 | 90/222 | 0.75 | na |
| Amyloid positive (%) | 10% (6/61) | 26% (8/31) | 36% (8/22) | 0.01 | na |
| MMSE | 29.1 ± 1.4 | 29.4 ± 0.9 | 29.6 ± 0.9 | 0.001 | NC, HT > HM |
| Plasma NfL | 18.0 ± 12.4 | 17.1 ± 9.1 | 16.2 ± 8.8 | 0.46 | na |
| Adjusted plasma NfL | 15.0 ± 3.5 | 15.5 ± 4.0 | 14.4 ± 3.4 | 0.005* | HM, HT > NC |
| Hypometabolic convergence index | 9.9 ± 5.2 | 10.0 ± 5.4 | 7.7 ± 3.1 | 0.01 | HT > NC |
| Relative hippocampal volumea | 5.2 ± 6.8 | 5.2 ± 7.5 | 5.4 ± 6.3 | 0.10 | na |
| White matter hyperintensity volume (cm3) | 5.7 ± 9.3 | 5.2 ± 7.0 | 5.3 ± 7.7 | 0.98 | na |
| PiB SUVR | 1.4 ± 0.3 | 1.4 ± 0.3 | 1.2 ± 0.2 | 0.001 | HM, HT > NC |
| AV-1451 tau meta ROI | 1.2 ± 0.1 | 1.2 ± 0.2 | 1.2 ± 0.1 | 0.66 | na |
| AVLT total learning | 43.0 ± 10.9 | 44.9 ± 10.7 | 46.6 ± 10.5 | 0.03 | HM < NC |
| AVLT delayed recall | 7.3 ± 4.2 | 8.2 ± 3.9 | 8.7 ± 3.6 | 0.03 | HM < NC |
aScaled to 1000X