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. Author manuscript; available in PMC: 2023 Apr 10.
Published in final edited form as: Mol Psychiatry. 2022 Dec 8;28(3):1101–1111. doi: 10.1038/s41380-022-01904-0

Fig. 4. JB2 rescues behavioral impairments in adult male Shank3+/− mice.

Fig. 4

a–e JB2 rescued wide variety deficits in adult male Shank3+/− mice in the behavioral domains. (a) Paw slips F (2, 28) = 195.2, (b) latency to righting F (2, 28) = 490.3 on a wire grid, and c grip strength F (2, 28) = 30.67. d Y-maze F (2, 28) = 21.62 and (e) NOR learning F (2, 25) = 31.93. The discrimination index (DI) [(time spent exploring the novel object—time spent exploring the familiar object)/total exploration time] was then calculated for retention trials. f Syllable numbers of adult male mice. F (2, 28) = 46.01. g Complex ultrasonic vocalizations of adult male mice. F (2, 28) = 97.84. One-way analysis of variance was followed by Bonferroni post hoc tests. *p < 0.05; ***p < 0.001 vs wild-type vehicle and ###p < 0.001 vs Shank3+/− vehicle. All data are represented as mean ± SEM. See also supplementary Fig. 6.