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. Author manuscript; available in PMC: 2023 Apr 10.
Published in final edited form as: Mol Psychiatry. 2022 Dec 8;28(3):1101–1111. doi: 10.1038/s41380-022-01904-0

Fig. 5. JB2 produced therapeutic-like effects in Shank3+/− mice using direct mouse-to-human non-invasive translational measures.

Fig. 5

a Firing rate of cortical neurons at DIV28 from an MEA plate. F(3, 116) = 15.39. b Adult male mice with surgically implanted mPFC skull screws were tested for theta train-induced seizure thresholds F (1, 118) = 10.104. Two-way analysis of variance was followed by Bonferroni post hoc tests. c N100 latencies in response to an auditory tone F (2, 24) = 86.45. d Alpha peak frequency F (2, 24) = 9.181. e, f Adult male mice with surgically implanted neck EMG electrodes (cerebellar reference) were tested for theta train-induced seizure thresholds. Amplitude (e) F (2, 24) = 18.42 and frequency (f) F (2, 24) = 62.81 were measured. One-way analysis of variance was followed by Bonferroni post hoc tests. *p < 0.05; **p < 0.01; ***p < 0.001 vs wild-type vehicle and #p < 0.05; ##p < 0.01; ###p < 0.001 vs Shank3+/− vehicle. All data are represented as mean ± SEM.