Table 4.
Multivariate analysis using 2-variable models.
| Model | Variable | HR | CI | P-value |
|---|---|---|---|---|
| Model for OS | HCT-CI (≥3 vs <3) | 6.71 | 2.35–19.2 | <0.001 |
| Donor gender (Men vs Women) | 0.21 | 0.08–0.56 | 0.002 | |
| Model for RFS | HCT-CI (≥3 vs <3) | 2.36 | 1.12–4.99 | 0.024 |
| Recipient CMV (Positive vs Negative) | 0.46 | 0.22–0.97 | 0.041 | |
| Model for NRM | Age at BMT per 10 year increase | 2.30 | 1.22–4.34 | 0.010 |
| HCT-CI (≥3 vs <3) | 5.11 | 1.55–16.9 | 0.007 | |
| Model 1 for relapse | Spleen Size (≥22 cm + prior splenectomy vs <22 cm) | 6.46 | 1.85–22.6 | 0.004 |
| Age at BMT per 10 year increase | 0.39 | 0.18–0.81 | 0.012 | |
| Model 2 for relapse | Spleen Size (≥22 cm + prior splenectomy vs <22 cm) | 6.04 | 1.93–18.9 | 0.002 |
| Recipient CMV serostatus (Positive vs Negative) | 0.28 | 0.09–0.90 | 0.032 | |
| Model 3 for relapse | Spleen Size (≥22 cm + prior splenectomy vs <22 cm) | 4.73 | 1.18–18.9 | 0.028 |
| Graft Source (BM vs PB) | 3.34 | 0.90–12.4 | 0.07 | |
| Model 4 for relapse | Age at BMT per 10 year increase | 0.29 | 0.14–0.62 | 0.001 |
| Recipient CMV serostatus (Positive vs Negative) | 0.23 | 0.07–0.70 | 0.010 | |
| Model 5 for relapse | Age at BMT per 10 year increase | 0.34 | 0.16–0.73 | 0.006 |
| Graft Source (BM vs PB) | 5.38 | 1.57–18.4 | 0.007 | |
| Model 6 for relapse | Recipient CMV serostatus (Positive vs Negative) | 0.44 | 0.14–1.38 | 0.16 |
| Graft Source (BM vs PB) | 3.71 | 1.31–10.5 | 0.014 | |
| Model 7 for relapse | Spleen Size (≥22 cm + prior splenectomy vs <22 cm) | 5.47 | 1.58–18.9 | 0.007 |
| Year of BMT per 1 year increase | 0.80 | 0.66–0.98 | 0.028 | |
| Model 8 for relapse | Age at BMT per 10 year increase | 0.34 | 0.14–0.80 | 0.013 |
| Year of BMT per 1 year increase | 0.69 | 0.54–0.87 | 0.002 | |
| Model 9 for relapse | Recipient CMV serostatus (Positive vs Negative) | 0.33 | 0.11–0.97 | 0.043 |
| Year of BMT per 1 year increase | 0.76 | 0.64–0.89 | 0.001 | |
| Model 10 for relapse | Graft Source (BM vs PB) | 3.50 | 1.16–10.6 | 0.026 |
| Year of BMT per 1 year increase | 0.82 | 0.68–0.98 | 0.028 |
BM bone marrow, BMT blood or marrow transplantation, CI 95% confidence intervals, CMV cytomegalovirus, HCT-CI Hematopoietic Cell Transplantation-specific Comorbidity Index, HR Hazard ratio, NRM non-relapse mortality, OS overall survival, PB peripheral blood, RFS relapse free survival.