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. 2023 Mar 27;13:1116277. doi: 10.3389/fcimb.2023.1116277

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Copyright © 2023 Li, Li, Cheng, Liu, Zhao, Liu, Chen, Sun, Zhai, Wu, Yan, Sun and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microbial composition in long-term depression and co-occurrence of the species. (A) α-phylogenetic diversity analysis of 4-week CUMS and 8-week CUMS rats. (B) OPLS-DA showed that the gut microbial composition of 8-week CUMS rats was significantly different from that of 4-week CUMS rats. (C) Relative abundance of gut microbes at the species level. (D) Altered species (top 20) in the long-term depression group. (E) Co-occurrence of the species altered in the depression groups at the g and p levels.