Table 1. ADME properties calculation of virtually screened compounds using PreADMET (https://preadmet.bmdrc.kr/adme/).

Compound	Human intestinal absorption	Cell permeability	Cell permeability maden darby canine kidney	In-vitro p-glycoprotein inhibition	Permeability of blood-brain barrier
	HIA (%)	CaCo-2 (nm/sec)	PMDCK (nm/sec)	P-gp inhibition	BBB (%)
C1	100.000	22.281	204.401	Non	1.499
C2	96.912	14.758	2.171	Non	0.154
C3	97.039	19.580	1.510	Non	0.181
C4	97.063	4.271	4.139	Inhibitor	0.736
C5	97.276	11.180	0.667	Non	1.564