Table 2. Pharmacokinetics properties and biological activities of top five virtually screened compounds (C1, C2, C3, C4, and C5), as determined by web server PASS ( http://www.pharmaexpert.ru/passonline/).

COMPOUND	Possibility of activity (p a )	Possibility of inactive(p i )	Biological activities
C1	0.150 0.162 0.784 0.637	0.141 0.153 0.006 0.018	Antipruritic, non-allergic Antibacterial Proteasome ATPase inhibitor Insulysin inhibitor
C2	0.411 0.863 0.253 0.142	0.049 0.004 0.093 0.131	Antiallergic Omptin inhibitor Alzheimer’s disease treatment Antineoplastic (renal cancer)
C3	0.243 0.338 0.090 0.140	0.196 0.016 0.073 0.010	Insulysin inhibitor Antineoplastic Lipoxygenase inhibitor Sulfonylureas
C4	0.808 0.650 0.290 0.258	0.005 0.009 0.070 0.138	Ant obesity Antidiabetic Alzheimer’s disease treatment Antineoplastic (Multi myeloma)
C5	0.231 0.379 0.734 0.169	0.021 0.049 0.031 0.162	Osteoarthritis treatment Antidiabetic Nootropic Diabetic nephropathy treatment