Table 6.
Cut off, Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value of Different Laboratory Parameters Associated with Pulmonary Embolism Occurrence
| Items | TLC | Absolute Lymphocytic Count | D- Dimer | Ferritin | Platelets | ESR | CRP |
|---|---|---|---|---|---|---|---|
| AUC (95% CI) | 0.790 (0.697–0.866) | 0.771 (0.675–0.849) | 0.889 (0.810–0.943) | 0.579 (0.476–0.678) | 0.719 (0.620–0.805) | 0.642 (0.539–0.736) | 0.593 (0.489–0.690) |
| P-value | <0.001 | <0.001 | <0.001 | 0.1747 | 0.003 | 0.0108 | 0.2298 |
| Cut off | ≤2800 | ≤0.66 | >1000 | >167 | ≤180×103 | >35 | >15 |
| Sensitivity% (95% CI) | 38.89% (17.3–64.3) | 27.78% (9.7–53.5) | 83.33% (58.6–96.4) | 94.44% (72.7–99.9) | 83.33% (58.6–96.4) | 83.33% (58.6–96.4) | 83.33% (58.6–96.4) |
| Specificity% (95% CI) | 97.53% (91.4–99.7) | 98.77% (93.3–100) | 85.19% (75.6 −92.1) | 46.91% (35.7 −58.3) | 74.07% (63.1–83.2) | 48.15% (36.9–59.5) | 51.85% (40.5–63.1) |
| PPV (95% CI) | 77.8% (44.2–93.9) | 83.3% (38.3–97.6) | 55.6% (41.6–68.7) | 28.3% (23.8–33.3) | 41.7% (31.9–52.1) | 26.3% (21.0–32.4) | 27.8% (22.1–34.3) |
| NPV (95% CI) | 87.8% (83.2–91.2) | 86% (82.2–89.1) | 95.8% (89.1–98.5) | 97.4% (84.8–99.6) | 95.2% (87.6–98.3) | 92.9% (81.9–97.4) | 93.3% (83.0–97.6) |
Abbreviations: AUC, Area under the curve; CI, Confidence interval; NPV, Negative predictive value; PPV, Positive predictive value; TLC, total leucocytic count.