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. Author manuscript; available in PMC: 2023 Apr 10.
Published in final edited form as: Nat Genet. 2022 Aug 4;54(11):1664–1674. doi: 10.1038/s41588-022-01140-w

ED Fig 2. CLL biological pathways affected by candidate driver genes.

ED Fig 2.

a. Schema of CLL pathways containing previously identified (black) and novel (magenta) putative driver genes (see Supplementary Table 6). Novel drivers cluster in central processes driving CLL (e.g., DNA damage, chromatin modification, RNA processing)1,2, but also highlight new pathways not previously implicated by driver genes (e.g., cytoskeleton and extracellular matrix, proteostasis, metabolism). Asterisks - mutated genes discovered by CLUMPs. b. Stacked barplot ranked by the number of candidate driver genes per CLL pathway. Magenta bars show the number of newly identified drivers in each pathway.