Characteristic analysis of Perillae Fructus oil nanoparticles. (a) The SEM appearance of Perillae Fructose oil nanoparticles (scale bar: 200 nm). (b) The size distribution of nanoparticles with an average diameter of 316.74 nm. (c) The zeta potential of nanoparticles with a surface charge of +2.9 mV. (d) The absorption spectra of Perillae Fructus oil, nanoparticles, and yeast shell. (e) The release efficiency of nanoparticles in gastric acid (3.83%) or intestinal fluid (~91.34%). (f) Analysis of the antioxidation activity of Perillae Fructus oil (PFO), nanoparticles in gastric acid (NP‐GA), and nanoparticles in intestinal fluid (NP‐IJ) through the DPPH method, in which vitamin C (Vc) was used as an indicator. (g) Analysis of the preservation stability of Perillae Fructus oil (PFO), nanoparticles in gastric acid (NP‐GA), and nanoparticles in intestinal fluid (NP‐IJ) through the DPPH method. The different capital letters indicate extremely significant differences (p < .01). The different lowercase letters indicate significant differences (p < .05). Vc, vitamin C; PFO, Perillae Fructus oil; NP‐GA, nanoparticle in gastric acid; NP‐IJ, nanoparticle in intestinal fluid.