Table 2. Cell phenotypes in the brain of SIV+ NHPs.
| SIV+ | P value | |||||||
|---|---|---|---|---|---|---|---|---|
| SIV- | Acute | Chronic | VS | SIV- vs. Acute | SIV- vs. Chronic | SIV- vs. VS | Chronic vs. VS | |
| Iba1 | 9.32 (8.18, 11.4) | 18.9 (17.1, 20.0) | 20.9 (15.7, 25.7) | 20.0 (17.4, 28.7) | 0.029 | 0.004 | 0.008 | 0.965 |
| GFAP | 17.7 (15.4, 20.6) | 12.5 (11.2, 14.8) | 14.0 (12.5, 17.7) | 9.48 (7.71, 20.8) | 0.057 | 0.170 | 0.177 | 0.091 |
ART: antiretroviral therapy, GFAP: glial fibrillary acidic protein, Iba1: ionized calcium binding adaptor molecule 1, NHP: nonhuman primate, SIV: simian immunodeficiency virus, VS: virally suppressed
Percentage of total cells (Median and interquartile range shown)
P value as determined by Mann Whitney U Test (P<0.05 statistically significant)
Bold values indicate significance (P<0.05), underlined values indicate trend (P>0.05, <0.1)