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. 2023 Feb 13;324(4):C951–C962. doi: 10.1152/ajpcell.00528.2022

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Licensed under Creative Commons Attribution CC-BY 4.0. Published by the American Physiological Society.

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Figure 4. — Immunofluorescence staining analysis of kidney. A: representative micrographs of kidney sections from each treatment group (×200, scale bar = 100 μm). B: cytotoxic T cells (CD8⁺ cells/total cells, %): no statistical difference between groups (Sham + PBO: n = 7, 5/6Nx + TELM: n = 7, 5/6Nx + 3 mg EMPA: n = 9; 5/6Nx + 15 mg EMPA: n = 11; 5/6Nx + PBO: n = 9). C: helper T cells (CD4⁺ cells/total cells, %): no statistical difference between groups (Sham + PBO: n = 7, 5/6Nx + TELM: n = 7, 5/6Nx + 3 mg EMPA: n = 9; 5/6Nx + 15 mg EMPA: n = 11; 5/6Nx + PBO: n = 9). D: macrophages (CD68+, RFU): 5/6Nx + PBO was higher than Sham + PBO group (Sham + PBO: n = 5, 5/6Nx + TELM: n = 5, 5/6Nx + 3 mg EMPA: n = 8; 5/6Nx + 15 mg EMPA: n = 7; 5/6Nx + PBO: n = 7). The arrows point to CD68+ cells. Values displayed are means ± SE. *P < 0.05, significantly different from 5/6Nx + PBO. EMPA, empagliflozin; 5/6Nx, 5/6 nephrectomized rat model; PBO, placebo; RFU, relative fluorescence unit; Sham, sham operation; TELM, telmisartan.