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. 2023 Feb 25;51(6):2586–2601. doi: 10.1093/nar/gkad100

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Scheme 1. — Synthesis of TO1-biotin analogs. Reagents and conditions: (i) TEA, CH₂Cl₂; (ii) Ac₂O, reflux; (iii) CuI, TBTA, DIPEA, CH₃OH/CH₃CN, rt, then preparative HPLC.