Effects of chronic restraint stress (CRS) on depression- and anxiety-like behaviors. A) Schematic drawing of the experimental timeline. B) Immobility durations in the TST of control mice and CRS mice. C) Latency to feed in the NSFT of control mice and CRS mice. D) Total distances in the OFT of control mice and CRS mice. E, F, and G) Distances, entries, and time into the center, respectively, of control mice and CRS mice. H) Total distances in the open and closed arms in the EPMT of control mice and CRS mice. I, J, and K) Percent of the distances, entries, and time into the open arms, respectively, of control mice and CRS mice. *p < 0.05, **p < 0.01, compared with control mice, n = 12–14 per group.