Table 3.

Factors Associated With All-Cause Death and/or Re-Transplantation

	Univariate Analysis			Multivariate Analysis
	HR	95% CI	p value	HR	95% CI	p value
Recipient Age, per 1 yr	1.02	0.98–1.04	0.46
Donor Cytomegalovirus IgG Positive (%)	1.57	0.64–4.20	0.33
Diabetes at Baseline	1.82	0.52–5.05	0.32
Hypertension at Baseline	0.33	0.05–1.18	0.09
Hyperlipidemia at Baseline	0.54	0.16–1.50	0.25
Total Cholesterol at 1 yr, per 1 mg/dl	1.01	0.996–1.02	0.16
Triglycerides at 1 yr, per 1 mg/dl	1.00	0.997–1.00	0.58
Insulin Use	1.80	0.67–4.40	0.23
LVEF at 1 yr, per −1%	0.98	0.93–1.03	0.38
Acute Cellular Rejection Grade ≥2R During the First Year	4.36	1.79–10.96	0.002	3.49	1.30–9.80	0.01
rATG	0.38	0.02–2.25	0.32
Tacrolimus	0.24	0.04–0.89	0.03	0.22	0.03–0.82	0.02
Sirolimus	2.24	0.86–6.50	0.09
Female Donor	1.94	0.75–4.72	0.17
Donor-recipient Sex Mismatch	0.37	0.06–1.28	0.13
Tansplant-period (2002 – 2007 vs. 2008 – 2013)	1.74	0.44–8.53	0.44
Donor Atherosclerosis (MIT at Baseline ≥ 0.5mm)	0.65	0.27–1.59	0.34
Baseline Vessel Volume, per 1%	1.00	0.89–1.13	0.97
Baseline Lumen Volume, per 1%	1.02	0.89–1.17	0.77
Baseline Intimal volume, per 1%	0.92	0.64–1.22	0.58
Increase in MIT ≥0.5mm During the First Year	1.46	0.53–5.17	0.49
Delta Vessel Volume During the First Year
Entire	0.95	0.92–0.99	0.01
Proximal	0.97	0.94–0.998	0.04
Middle	0.97	0.94–1.01	0.11
Distal	0.96	0.93–0.99	0.007	0.96	0.87–1.05	0.38
Delta Lumen Volume During the First Year
Entire	0.95	0.92–0.99	0.005
Proximal	0.97	0.94–0.995	0.02
Middle	0.97	0.94–1.00	0.08
Distal	0.96	0.93–0.99	0.007	1.00	0.92–1.10	0.99
Delta Intimal Volume During the First Year
Entire	1.00	0.99–1.01	0.48
Proximal	1.00	1.00–1.01	0.32
Middle	1.00	0.99–1.01	0.52
Distal	1.00	0.99–1.01	0.89
MB	3.80	1.27–16.30	0.01	5.06	1.65–22.17	0.003

All variables with a p-value ≤0.05 on univariate analysis were included in multivariate analysis.

CI = confidence interval; HR = hazard ratio; MIT = maximum intimal thickness; other abbreviations as in Table 1.