Table 4.

Factors Associated With Cardiac Death and/or Re-Transplantation

	Univariate Analysis			Multivariate Analysis
	HR	95% CI	p value	HR	95% CI	p value
Recipient Age, per 1 yr	0.97	0.95–0.998	0.03	0.97	0.93–1.00	0.051
Donor Cytomegalovirus IgG Positive (%)	1.20	0.42–3.64	0.74
Diabetes at Baseline	1.13	0.18–4.17	0.87
Hypertension at Baseline	0.24	0.01–1.21	0.09
Hyperlipidemia at Baseline	0.33	0.05–1.23	0.11
Total Cholesterol at 1 yr, per 1 mg/dl	1.01	0.99–1.02	0.22
Triglycerides at 1 yr, per 1 mg/dl	1.00	0.995–1.00	0.96
Insulin Use	1.85	057–5.38	0.28
LVEF at 1 yr, per −1%	0.99	0.94–1.06	0.76
Acute Cellular Rejection Grade ≥2R During the First Year	2.61	0.85–7.61	0.09
rATG	0.91	0.04–7.22	0.93
Tacrolimus	0.41	0.06–1.59	0.22
Sirolimus	3.28	1.11–9.68	0.03	3.68	0.99–14.40	0.052
Female Donor	1.73	0.53–5.01	0.34
Donor-recipient Sex Mismatch	0.53	0.08–1.94	0.37
Transplant-period (2002 – 2007 vs. 2008 – 2013)	1.34	0.26–10.21	0.74
Donor Atherosclerosis (MIT at Baseline ≥ 0.5mm)	0.87	0.30–2.66	0.80
Baseline Vessel Volume, per 1%	0.94	0.82–2.08	0.40
Baseline Lumen Volume, per 1%	0.93	0.66–1.35	0.93
Baseline Intimal volume, per 1%	1.01	0.94–1.07	0.73
Increase in MIT ≥0.5mm During the First Year	1.97	0.54–12.72	0.33
Delta Vessel Volume During the First Year
Entire	0.95	0.92–0.995	0.03
Proximal	0.97	0.93–1.00	0.07
Middle	0.98	0.94–1.02	0.34
Distal	0.95	0.91–0.99	0.004	1.06	0.93–1.19	0.38
Delta Lumen Volume During the First Year
Entire	0.96	0.92–0.99	0.03
Proximal	0.97	0.94–1.00	0.09
Middle	0.98	0.95–1.02	0.26
Distal	0.95	0.91–0.99	0.004	0.91	0.81–1.00	0.12
Delta Intimal Volume During the First Year
Entire	0.99	0.98–1.01	0.56
Proximal	1.00	0.98–1.01	0.41
Middle	1.00	0.99–1.01	0.96
Distal	1.00	0.98–1.01	0.60
MB	4.01	1.09–25.80	0.04	4.92	1.18–34.60	0.03

All variables with a p-value ≤0.05 on univariate analysis were included in multivariate analysis. Abbreviations as in Table 1 and 3.