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Major pathways of mechanotransduction signal epigenetic changes in response to tension. The figure shows the main pathways responsible for the transmission of the signal from the outside of the cell to the nucleus. Boxes represent modalities of response to tensile stretches. Created with BioRender. Abbreviations: LAD, lamina-associated domain; LINC, linker of nucleoskeleton and cytoskeleton; NPC, nuclear pore complex; TAD, topologicallly associating domain.
