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. Author manuscript; available in PMC: 2024 Apr 10.
Published in final edited form as: Cancer Cell. 2023 Mar 23;41(4):740–756.e10. doi: 10.1016/j.ccell.2023.03.002

Figure 5. Statin-induced growth inhibition is pyroptosis dependent.

Figure 5

A, Expression of GSDMD in the indicated OVCA429 cells was determined by immunoblot.

B, Expression of caspase 1 in the indicated OVCA429 cells was determined by immunoblot.

C, Dose response curves of the indicated OVCA429 cells to simvastatin were determined by colony formation assay. n=4 independent experiments.

D, Dose response curves of the indicated OVCA429 cells to atorvastatin were determined by colony formation assay. n=4 independent experiments.

E, Dose response curves of the indicated OVCA429 cells treated with or without MCC950 (1 μM), Ac-YVAD-CMK (20 μM) and Ac-YVAD-CHO (20 μM) to simvastatin was determined by colony formation assay. n=4 independent experiments.

Error bars represent mean with SEM.