Table 2.

Estimates of ampicillin-sulbactam pharmacokinetic parameters from the final model with covariate and model selection

PK parameter	PK value from final PK model
	Ampicillin					Sulbactam
	Mean	SD	CV %	Median	Shrink (%)	Mean	SD	CV %	Median	Shrink (%)
CL (L/h)	5.58	2.57	46.1	5.07	0.04	4.79	2.05	42.8	4.47	3.15
V (L)	12.6	2.16	17.2	12.7	1.85	15.4	4.73	30.8	14.6	2.85
KCP (L/h)	0.90	0.78	86.6	0.44	0.13	0.42	0.41	96.8	0.32	14.0
KPC (L/h)	0.17	0.79	67.3	1.11	4.81	0.69	0.56	81.7	0.79	5.55

Compartment model	− 2LL	AIC		− 2LL	AIC
Model selection
One	356	363		283	290
Two (with KPC–KCP)	315	326		258	269
Two (with KPC–KCP and the additional of SeCr on CL)	306	317		249	260
Two (with KPC–KCP and the additional of eGFRCKD-EPI without allometric scale on CL)a	312	323		256	268
Two (with KPC–KCP and the additional of eGFRCKD-EPI with allometric scale on CL)a	314	325		252	263

− 2LL − 2*Log-likelihood at each cycle, AIC Akaike Information Criterion at each cycle, CL clearance, eGFR estimated glomerular filtration rate, K_CP the rate constant from the central compartment to the peripheral compartment, K_PC the rate constant from the peripheral compartment to the central compartment, PK pharmacokinetic, V volume of central compartment

^aAllometric scale value: 0.75