Table 3.
The MIC breakpoints attaining 60% fT>MIC for ampicillin-sulbactam dosing regimens at different SeCr concentrations
| Dosing regimen ampicillin-sulbactam | MIC breakpoints (mg/L)a | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ampicillin | Sulbactam | |||||||||
| SeCr 6 mg/dL | SeCr 2 mg/dL | SeCr 1.5 mg/dL | SeCr 1 mg/dL | SeCr 0.7 mg/dL | SeCr 6 mg/dL | SeCr 2 mg/dL | SeCr 1.5 mg/dL | SeCr 1 mg/dL | SeCr 0.7 mg/dL | |
| 1.5 g q24-h bolus | 4/8 | – | – | – | – | 2/2 | – | – | – | – |
| 1.5 g q24-h infusion | 4/8 | – | – | – | – | 2/4 | – | – | – | – |
| 3 g q24-h bolus | 8/16 | – | – | – | – | 4/4 | – | – | – | – |
| 3 g q24-h infusion | 8/16 | – | – | – | – | 4/8 | – | – | – | – |
| 1.5 g q12-h bolus | – | 2/4 | – | – | – | – | 1/1 | – | – | – |
| 1.5 g q12-h infusion | – | 4/4 | – | – | – | – | 2/2 | – | – | – |
| 3 g q12-h bolus | – | 4/8 | – | – | – | – | 2/2 | – | – | – |
| 3 g q12-h infusion | – | 8/8 | – | – | – | – | 4/4 | – | – | – |
| 1.5 g q8-h bolus | – | – | 2/4 | 1/2 | 0.5/0.5 | – | – | 1/1 | 0.5/0.5 | 0.125/0.25 |
| 1.5 g q8-h infusion | – | – | 4/8 | 2/4 | 2/2 | – | – | 2/4 | 2/2 | 1/1 |
| 3 g q8-h bolus | – | – | 4/8 | 2/4 | 1/1 | – | – | 2/2 | 1/1 | 0.25/0.5 |
| 3 g q8-h infusion | – | – | 8/8 | 4/4 | 4/4 | – | – | 4/8 | 4/4 | 2/2 |
| 1.5 g q6-h bolus | – | – | 4/4 | 2/2 | 1/1 | – | – | 2/2 | 1/1 | 0.5/0.5 |
| 1.5 g q6-h infusion | – | – | 4/8 | 4/8 | 4/4 | – | – | 4/4 | 2/4 | 2/2 |
| 3 g q6-h bolus | – | – | 8/8 | 4/4 | 2/2 | – | – | 4/4 | 2/2 | 1/1 |
| 3 g q6-h infusion | – | – | 8/16 | 8/8 | 8/8 | – | – | 8/8 | 4/8 | 4/4 |
The first and second value presented in each PK/PD breakpoint represented the highest MIC at which PTA ≥ 90% for the first and fifth administration, respectively
Not simulated; q24 h, 12 h, 8 h, 6 h indicates the dose is given every 24 h, 12 h, 8 h, 6 h, respectively
MIC minimum inhibitory concentration, PD pharmacodynamic, PK pharmacokinetic, PTA probability of target attainment
aThe highest MIC at which the PTA ≥ 90%