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. 2023 Apr 10;13:5846. doi: 10.1038/s41598-023-31959-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of TAF15 inhibits the cell proliferation, migration and invasion of GC in vitro. (a–c) The knockdown efficiency of TAF15 shRNA in HGC27 and AGS cells. Knocked down TAF15 by use of two shRNAs (sh1 and sh2) and scrambled shRNA (scr) as control in AGS and HGC27 cells. TAF15 expression level was significantly downregulated in sh1 and sh2 group when compared to scr group as detected by western blotting. p values were calculated by One-way ANOVA. (d,e) CCK-8 assay detected the proliferation of AGS and HGC27 after cell transfection. (f–h) Colony formation assay detected the proliferation of AGS and HGC27 after cell transfection. (i–n) Transwell assay was conducted to analyse the migration and invasion of AGS and HGC27 after cell transfection. (o–q) Wound healing assay detected the migration of GIST-882 and GIST-T1 after cell transfection. p values were calculated by One-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. All these experiments were repeated 3 times.