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. 2023 Apr 10;13:5846. doi: 10.1038/s41598-023-31959-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of TAF15 inhibits tumour growth of GC in vivo. (a,b) Xenograft tumours were obtained (n = 10) when nude mice were sacrificed by using the cervical dislocation method on day 25, and tumor volume was measured every day and a growth curve was drawn. The volumes of xenograft tumours in sh2 group were significantly smaller compared to the scr group. p value was calculated Kruskal–Wallis test. (c,d) Tumor weight was measured when nude mice were sacrificed and the weights of xenograft tumours in sh2 group were significantly lower compared to the scr group. p value was calculated by student-t test. (e,f) Western blotting analysis detected the TAF15 expression level of xenograft tumours in sh2 group and scr group. (g–j) Western blot analysis detected the expression levels of pRAF1/RAF1, pMEK/MEK and pERK/ERK in xenograft tumours of sh2 group and scr group. p value was calculated by student-t test. **p < 0.01, ***p < 0.001, ****p < 0.0001. Three replicates were performed.