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. 2023 Apr 10;14:2018. doi: 10.1038/s41467-023-37783-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Representative immunofluorescence images of trabecular regions of femurs showing an improvement of aging-related BM niche defects following NTN1 treatment. b, c Analysis of BM niche function following NTN1 treatment of aged mice by determining vascular leakiness (10 kDa dextran extravasation), vascular perfusion (Hypoxyprobe staining), and BM adiposity (PLIN1 + adipocytes/high power field) in both trabecular b, and diaphyseal c regions of femoral BM, as compared to young controls (N = 5 mice/group). Data is presented as the mean ± standard error of the mean (SEM). Statistical significance determined using One-Way ANOVA with Tukey’s correction for multiple comparisons. *P < 0.05; **P < 0.01; ***P < 0.001. ns denotes statistically not significant.