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. 2023 Apr 10;14:2018. doi: 10.1038/s41467-023-37783-4

Fig. 9. NTN1 restores the regenerative capacity of aged HSCs.

Fig. 9

a Experimental design for NTN1 treatment following a single dose of 5-FU. b–d Complete blood counts quantifying WBCs b, Platelets c, and RBCs d (PBS N = 19 (Days 0 & 3), N = 17 (Days 7 &10), N = 6 (Day 14), NTN1 N = 20 (Days 0, 3 & 7), N = 18 (Day 10), N = 7 (Day 14)). e Experimental design for NTN1 treatment following serial 5-FU treatment. f Kaplan-Meier survival curve (PBS N = 18, NTN1 N = 12). Statistical significance determined using Log-rank (Mantel-Cox) test. g Analysis of total body weight loss following serial 5FU injections (PBS N = 25 (Days 0, 9), N = 15 (Day 14), N = 15 (Day 35), N = 14 (Day 45), N = 4 (Day 70), N = 4 (Day 105), N = 1 (Day 140); NTN1 N = 20 (Days 0, 9), N = 12 (Days 14, 35, 45, 70, 105 & 140)). Data is presented as the mean ± standard error of the mean (SEM). Statistical significance determined using two-tailed unpaired t-test. *P < 0.05; **P < 0.01; ***P < 0.001. ns denotes statistically not significant.