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. 2023 Apr 10;8:152. doi: 10.1038/s41392-023-01400-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The natural course of diabetic vasculopathy in mice. Streptozotocin induced in C57BL/6 mice simulate type 1 diabetes in human; db/db mice simulate type 2 diabetes in human. Vasculopathy in different organs appears over a period of time, In C57BL/6 mice Streptozotocin induced in C57BL/6 mice develop typical microangiopathy mostly at 8‒10 weeks after the onset of DM and develop advanced microangiopathy at 12–16 weeks. db/db mice develop microangiopathy at about 20 weeks of age and develop advanced microangiopathy at 34 weeks