Table 5.

Certainty of evidence (CerQual).

Review finding	Studies contributing to the review finding	Assessment of methodological limitations	Assessment of relevance	Assessment of coherence	Assessment of adequacy of data	Overall CerQual assessment of confidence	Explanation of judgement
Negative impact of migraine symptoms on overall life	Ruiz De Velasco et al., 2003; Belam et al., 2005; Peters et al., 2005; Ramsey, 2012; Rutberg and Öhrling, 2012; Palacios-Ceña et al., 2017; Estave et al., 2021	Minor methodological limitations (two studies with no limitations, one with minor limitations on research design, recruitment strategy and data collections, one study with moderate methodological limitations on recruitment strategy and the other studies have minor methodological limitations)	Substantial concerns about relevance (all the studies included only Caucasian people)	Minor concerns about coherence (data reasonably consistent within and across all studies)	Minor concerns about adequacy (seven studies that offered together moderately rich data overall)	Moderate confidence	This finding was graded as moderate confidence because of minor concerns regarding methodological limitations, coherence and adequacy; though substantial concerns about relevance.
Impact of migraine on family, work and social relationships	Cottrell et al., 2002; Ruiz De Velasco et al., 2003; Belam et al., 2005; Peters et al., 2005; Ramsey, 2012; Rutberg and Öhrling, 2012; Palacios-Ceña et al., 2017; Scaratti et al., 2018; Estave et al., 2021	Minor methodological limitations (two studies with no limitations, one study with concerns on research design and data collection, one study with concerns with research design, recruitment strategy and data collection, one with moderate concern on recruitment strategy and the other studies have minor methodological limitations)	Substantial concerns about relevance (all the studies included only Caucasian people)	Minor concerns about coherence (data reasonably consistent within and across all studies)	Minor concerns about adequacy (nine studies that offered together moderately rich data overall)	Moderate confidence	This finding was graded as moderate confidence because of minor concerns regarding methodological limitations, coherence and adequacy; though substantial concerns about relevance.
Impact of migraine on emotional health	Ruiz De Velasco et al., 2003; Belam et al., 2005; Moloney et al., 2006; Ramsey, 2012; Rutberg and Öhrling, 2012; Palacios-Ceña et al., 2017; Scaratti et al., 2018; Estave et al., 2021	Minor methodological limitations (two studies with no limitations, one study with concern on research design, recruitment strategy and data collection, one study with minor concern on research design and data collection, one study with moderate concern on recruitment strategy and the other studies have minor methodological limitations)	Substantial concerns about relevance (all the studies included only Caucasian people)	Minor concerns about coherence (data reasonably consistent within and across all studies)	Minor concerns about adequacy (eight studies that offered together moderately rich data overall)	Moderate confidence	This finding was graded as moderate confidence because of minor concerns regarding methodological limitations, coherence and adequacy; though substantial concerns about relevance.
Coping strategies to deal with migraine	Belam et al., 2005; Moloney et al., 2006; Ramsey, 2012; Rutberg and Öhrling, 2012; Palacios-Ceña et al., 2017	Minor methodological limitations (two studies with no limitations, one study with minor concerns, one with concerns on research design and data collection and one with moderate concerns on recruitment strategy)	Substantial concerns about relevance (all the studies included only Caucasian people)	Minor concerns about coherence (data reasonably consistent within and across all studies)	Minor concerns about adequacy (eight studies that offered together moderately rich data overall)	Moderate confidence	This finding was graded as moderate confidence because of minor concerns regarding methodological limitations, coherence and adequacy; though substantial concerns about relevance.