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. 2023 Mar 28;14:1149478. doi: 10.3389/fphar.2023.1149478

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Copyright © 2023 Zhang, Cao, Zuo, Cheng, Liu, Xia, Ren, Deng, Wang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network pharmacology analysis. (A) The chemical structure of Bruceine (A,B) Venn diagram of Bruceine A targets and colon cancer-related targets. (C) PPI network of common targets of BA and CC. The larger the node and the darker the color is, which means the higher the degree of correlation. (D) Bar plot showing the top 21 hub genes in the PPI network. (E) The top 20 enriched KEGG pathways of target genes. (F) GO analysis of target genes.