Skip to main content
. 2023 Mar 5;13(5):1506–1519. doi: 10.7150/thno.79942

Figure 1.

Figure 1

Schematic diagram of the MBP technology in NK cells and expected role in the tumor site. (A) Schematic illustration of cytokine engineered MBP NK cells and functional difference between parental NK-92 cells and MBP NK cells. Because of self-stimulation via MBP IL-2, MBP NK cells can survive IL-2 deficient environment as well as can reduce systemic risks of hyperimmune activation induced by exogenous treatment of IL-2. (B) The fabrication of the microwell array sheet to generate a hematological tumor model with K562 cancer cells. (C) In the solid tumor spheroid model, A549 spheroid and NK-92 cells or MBP NK cells are co-cultured and observed using confocal microscopy. The chambers are made with a guide block insert, and the bottom surface is coated with poly hydroxyethyl methacrylate (MEMA).