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The “mulberry-fish-ponds model” (top left) to elucidate the dynamic reciprocity of mutualism between (bottom right) cancer cells and TME (e.g. CAFs synthesizing ECM components such as collagen and FN contributes to stromal stiffness, which in turn promotes cancer progression) in cancer ecosystem. Cancer cells and TME work together to build “a community with a shared future” for tumor ecology (ecosystem).
