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A close analogy of tumor-host interface and budding cells in NPC with the ecological nature. Land/sea transitional zone and isolated islands on earth (A,B). Tumor-host interface as the ecological transition zone, it often takes curved and finger-like shapes (C,D). Tumor buddings are similar to little islands separated from the continent (E, F). (A,B adapted from image.baidu; C-F adapted from our previous studies, Luo WR et al, (Ref.136,229) ).
