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. 2023 Mar 5;13(5):1571–1583. doi: 10.7150/thno.79945

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Long-term anti-tumor memory immune response. (A) Schematic illustration of tumor re-challenge assay schedules of 4T1 tumor bearing mouse model. The different treatments are as follows: (G1) PBS, (G2) PM under US irradiation (PM: 5 mg kg^-1) (G3) DAC + PM under US irradiation (DAC: 0.35 mg kg^-1; PM:5 mg kg^-1) and (G4) DAC + LPM under US irradiation (DAC: 0.35 mg kg^-1; LPM:5 mg kg^-1, containing LY364947: 0.43 mg kg^-1). (B) Tumor growth kinetics of tumor re-challenge assay. (C) Representative flow cytometric analysis of memory T cells within the spleen after tumor re-challenge assay. Absolute quantification of CD44⁺CD62L^- cells gating on CD3⁺CD4⁺ cells (D) and CD44⁺CD62L⁺ cells gating on CD3⁺CD4⁺ cells (E). Data are presented as the mean ± SD. Statistical significance was calculated via unpaired t-test. (ns, nonsignificant; *P < 0.05; ***P < 0.001).