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. 2023 Jan 17;82(4):515–526. doi: 10.1136/ard-2022-223595

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Objective signs of inflammation. Randomised set. Exploratory endpoints. Error bars show SD. (A) n=128 (BKZ) and n=126 (PBO) in BE MOBILE 1, n=221 (BKZ) and n=111 (PBO) in BE MOBILE 2; (B) At BL, n=79 (BKZ) and n=68 (PBO) in BE MOBILE 1, n=83 (BKZ) and n=45 (PBO) in BE MOBILE 2. At week 16, n=77 (BKZ), n=60 (PBO) in BE MOBILE 1, n=79 (BKZ) and n=43 (PBO) in BE MOBILE 2; (C) At BL, n=75 (BKZ) and n=65 (PBO) in BE MOBILE 1, n=82 (BKZ) and n=45 (PBO) in BE MOBILE 2. At week 16, n=73 (BKZ) and n=58 (PBO) in BE MOBILE 1, n=79 (BKZ) and n=43 (PBO) in BE MOBILE 2. MRI Berlin spine score ranges from 0 to 69; lower scores indicate less spinal inflammation and negative changes represent improvements. MRI SPARCC SIJ inflammation scores range from 0 to 72; lower scores indicate less SIJ inflammation and negative changes represent improvements. BKZ, bimekizumab; BL, baseline; CfB, change from baseline; hs-CRP, high-sensitivity C-reactive protein; MI, multiple imputation; nr-axSpA, non-radiographic axial spondyloarthritis; OC, observed case; PBO, placebo; Q4W, every 4 weeks; r-axSpA, radiographic axial spondyloarthritis; SIJ, sacroiliac joint; SPARCC, Spondyloarthritis Research Consortium of Canada.