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. 2022 May 25;72(5):984–994. doi: 10.1136/gutjnl-2021-326314

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Gene module enrichment between sexes in CC and non-CC genotypes. Preranked (after covariate adjustments) gene set enrichment analyses (GSEAs) showing sex enrichments of all weighted gene coexpression network analysis (WGCNA) modules (m1–m7) in CC (A) and non-CC (B) samples. Module enrichments are ranked by statistical significance (adjusted p values). (C) Preranked GSEAs with enrichment curves for immunoglobulin module (m7, left plot, false discovery rate (FDR) <<0.01), T-cell module (m4, middle plot, FDR<<0.01) and Mucosal Associated Invariant T (MAIT) cell signature (CD161+, right plot, FDR=0.003) between IFNL4 (interferon lambda 4) genotypes (non-CC versus CC) in overall analysis (all covariates control). Standard GSEAs (D) showing sex enrichments of immunoglobulin module in subsets of non-cirrhotic-CC with A viral variant in pos2570 (CC-A) (left plot, FDR<<0.01) and non-cirrhotic-non-CC with same viral variant (non-CC-A, FDR<<0.01) (right plot).