Table 1.
Association of RRM2 expression and clinical characteristics in HCC.
| Characteristics | Low expression of RRM2 | High expression of RRM2 | P |
|---|---|---|---|
| n | 187 | 187 | |
| OS event, n (%) | 0.023 | ||
| Alive | 133 (35.6%) | 111 (29.7%) | |
| Dead | 54 (14.4%) | 76 (20.3%) | |
| T stage, n (%) | 0.001 | ||
| T1 | 110 (29.6%) | 73 (19.7%) | |
| T2 | 37 (10%) | 58 (15.6%) | |
| T3 | 32 (8.6%) | 48 (12.9%) | |
| T4 | 5 (1.3%) | 8 (2.2%) | |
| N stage, n (%) | 0.629 | ||
| N0 | 116 (45%) | 138 (53.5%) | |
| N1 | 1 (0.4%) | 3 (1.2%) | |
| M stage, n (%) | 0.345 | ||
| M0 | 125 (46%) | 143 (52.6%) | |
| M1 | 3 (1.1%) | 1 (0.4%) | |
| Pathologic stage, n (%) | < 0.001 | ||
| Stage I | 103 (29.4%) | 70 (20%) | |
| Stage II | 36 (10.3%) | 51 (14.6%) | |
| Stage III | 32 (9.1%) | 53 (15.1%) | |
| Stage IV | 4 (1.1%) | 1 (0.3%) | |
| Tumor status, n (%) | 0.029 | ||
| Tumor free | 112 (31.5%) | 90 (25.4%) | |
| With tumor | 66 (18.6%) | 87 (24.5%) | |
| Gender, n (%) | 0.269 | ||
| Female | 55 (14.7%) | 66 (17.6%) | |
| Male | 132 (35.3%) | 121 (32.4%) | |
| Age, n (%) | 0.034 | ||
| ≤60 | 78 (20.9%) | 99 (26.5%) | |
| >60 | 109 (29.2%) | 87 (23.3%) | |
| Weight, n (%) | 0.103 | ||
| ≤70 | 85 (24.6%) | 99 (28.6%) | |
| >70 | 90 (26%) | 72 (20.8%) | |
| Height, n (%) | 0.154 | ||
| < 170 | 95 (27.9%) | 106 (31.1%) | |
| ≥170 | 78 (22.9%) | 62 (18.2%) | |
| BMI, n (%) | 0.946 | ||
| ≤25 | 89 (26.4%) | 88 (26.1%) | |
| >25 | 82 (24.3%) | 78 (23.1%) | |
| Residual tumor, n (%) | 0.902 | ||
| R0 | 167 (48.4%) | 160 (46.4%) | |
| R1 | 8 (2.3%) | 9 (2.6%) | |
| R2 | 1 (0.3%) | 0 (0%) | |
| Histologic grade, n (%) | < 0.001 | ||
| G1 | 41 (11.1%) | 14 (3.8%) | |
| G2 | 98 (26.6%) | 80 (21.7%) | |
| G3 | 44 (11.9%) | 80 (21.7%) | |
| G4 | 2 (0.5%) | 10 (2.7%) | |
| Adjacent hepatic tissue inflammation, n (%) | 0.713 | ||
| None | 66 (27.8%) | 52 (21.9%) | |
| Mild | 51 (21.5%) | 50 (21.1%) | |
| Severe | 10 (4.2%) | 8 (3.4%) | |
| AFP (ng/ml), n (%) | < 0.001 | ||
| ≤400 | 127 (45.4%) | 88 (31.4%) | |
| >400 | 18 (6.4%) | 47 (16.8%) | |
| Child-Pugh grade, n (%) | 0.366 | ||
| A | 118 (49%) | 101 (41.9%) | |
| B | 9 (3.7%) | 12 (5%) | |
| C | 1 (0.4%) | 0 (0%) | |
| Fibrosis. Ishak. score, n (%) | 0.336 | ||
| 0 | 46 (21.4%) | 29 (13.5%) | |
| 1/2 | 14 (6.5%) | 17 (7.9%) | |
| 3/4 | 14 (6.5%) | 14 (6.5%) | |
| 5/6 | 40 (18.6%) | 41 (19.1%) | |
| Vascular invasion, n (%) | 0.188 | ||
| No | 114 (35.8%) | 94 (29.6%) | |
| Yes | 51 (16%) | 59 (18.6%) | |
| Age, median (IQR) | 64 (54.5, 69) | 59 (51, 68) | 0.019 |
| Height, median (IQR) | 168 (162, 175) | 166 (160, 172) | 0.041 |
| Weight, median (IQR) | 71 (61, 85) | 69 (58, 79) | 0.075 |
| BMI, median (IQR) | 24.39 (21.89, 29.04) | 24.65 (21.32, 27.99) | 0.457 |
OS, Overall Survival; IQR, interquartile range.