Table 3.
Univariate and multivariate Cox proportional hazards analysis for RRM2 expression.
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| T stage | 370 | ||||
| T1&T2 | 277 | ||||
| T3&T4 | 93 | 2.598 (1.826-3.697) | <0.001 | 1.658 (0.225-12.238) | 0.620 |
| N stage | 258 | ||||
| N0 | 254 | ||||
| N1 | 4 | 2.029 (0.497-8.281) | 0.324 | ||
| M stage | 272 | ||||
| M0 | 268 | ||||
| M1 | 4 | 4.077 (1.281-12.973) | 0.017 | 1.826 (0.415-8.028) | 0.426 |
| Gender | 373 | ||||
| Female | 121 | ||||
| Male | 252 | 0.793 (0.557-1.130) | 0.200 | ||
| Age | 373 | ||||
| ≤60 | 177 | ||||
| >60 | 196 | 1.205 (0.850-1.708) | 0.295 | ||
| Pathologic stage | 349 | ||||
| Stage I &Stage II | 259 | ||||
| Stage III &Stage IV | 90 | 2.504 (1.727-3.631) | <0.001 | 1.392 (0.189-10.257) | 0.745 |
| Histologic grade | 368 | ||||
| G1&G2 | 233 | ||||
| G3&G4 | 135 | 1.091 (0.761-1.564) | 0.636 | ||
| Vascular invasion | 317 | ||||
| No | 208 | ||||
| Yes | 109 | 1.344 (0.887-2.035) | 0.163 | ||
| Tumor status | 354 | ||||
| Tumor free | 202 | ||||
| With tumor | 152 | 2.317 (1.590-3.376) | <0.001 | 1.867 (1.164-2.993) | 0.010 |
| Adjacent hepatic tissue inflammation | 236 | ||||
| None | 118 | ||||
| Mild &Severe | 118 | 1.194 (0.734-1.942) | 0.475 | ||
| AFP (ng/ml) | 279 | ||||
| ≤400 | 215 | ||||
| >400 | 64 | 1.075 (0.658-1.759) | 0.772 | ||
| RRM2 | 373 | ||||
| Low | 187 | ||||
| High | 186 | 1.698 (1.197-2.409) | 0.003 | 1.626 (1.010-2.619) | 0.045 |