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. 2023 Mar 28;14:1150803. doi: 10.3389/fimmu.2023.1150803

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Copyright © 2023 Huang, Huang, Ge, Yang, Chen, Xu, Wu, Zheng, Chen, Zhang and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IFN-γ inhibits the expression of CD226 and promotes T-cell exhaustion. (A) Pseudotime plot of CD8⁺TILs in ESCA constructed by R package Monocle2. (B) UMAP showed imputed expressions of CD226, IFNG, and TIGIT in all CD8⁺TILs. (C) Heatmap showed the correlation among CD226, IFNG, and TIGIT in all CD8⁺TILs. (D) Dot plot showed the expressions of selected genes in CD226⁺, TIGIT⁺, and CD226⁺TIGIT⁺CD8⁺TILs. (E) Heatmap showed regulon score of selected transcription factors in CD226⁺, TIGIT⁺, and CD226⁺TIGIT⁺CD8⁺TILs. (F) Heatmap showed the expressions of transcription factors (shown in E) in CD226⁺, TIGIT⁺, and CD226⁺TIGIT⁺CD8⁺TILs.