Table 1.

Association of TAC signatures with clinical variables at baseline

	TAC1			TAC2			TAC3			ICS-sensitive TAC1
	rho	P value	FDR	rho	P value	FDR	rho	P value	FDR	r	P value	FDR
Log sputum eosinophil counts	0.3181	0.0203	0.03045	−0.1503	0.2828	0.9292	−0.2281	0.1005	0.201	−0.1726	0.2164	0.82092
Log sputum neutrophil counts	0.5407	<0.0001	0.0003	0.02508	0.8585	0.9292	−0.2977	0.0304	0.1824	−0.0953	0.4973	0.82092
Log sputum macrophage counts	0.3391	0.013	0.026	−0.0125	0.9292	0.9292	−0.0914	0.5153	0.5471	0.0572	0.6841	0.82092
Log sputum lymphocyte counts	0.502	0.0001	0.0003	0.08958	0.5235	0.9292	−0.2358	0.0891	0.201	0.08615	0.5396	0.82092
FEV1 %predicted	−0.0935	0.4852	0.58224	0.01461	0.9133	0.9292	0.1402	0.2939	0.44085	0.06994	0.6019	0.82092
RV/TLC %predicted	0.0064	0.9618	0.9618	−0.0707	0.5978	0.9292	−0.0807	0.5471	0.5471	−0.02	0.8814	0.8814

FDR, false discovery rate; FEV₁, forced expiratory volume in 1 s; RV/TLC, residual volume/total lung capacity; TAC, transcriptome-associated cluster.