Table 2.
Number of CD4+ and CD8+ T-cell responders among HCWs and PwMS at T3
| Stimulation and type of T-cell response evaluation | Cytokine produced | T3 responders over total N (%) | ||
| HCWs 15 (100) |
PwMS 22 (100) |
P value* | ||
| Spike-specific CD4+ T cells | Any Th1 | 13 (86.6) | 5 (22.7) | 0.0001 |
| IFN-γ | 7 (46.6) | 5 (22.7) | 0.1267 | |
| TNF-α | 9 (60) | 0 (0) | <0.0001 | |
| IL-2 | 9 (60) | 0 (0) | <0.0001 | |
| Spike-specific CD8+ T cells | Any Th1 | 4 (26.6) | 2 (9.1) | 0.1544 |
| IFN-γ | 4 (26.6) | 2 (9.1) | 0.1544 | |
| TNF-α | 1 (6.6) | 0 (0) | 0.2195 | |
| IL-2 | 1 (6.6) | 0 (0) | 0.2195 | |
| CD4+ T cells response to SEB | Any Th1 | 15 (100) | 22 (100) | n/a |
| IFN-γ | 15 (100) | 22 (100) | n/a | |
| TNF-α | 15 (100) | 21 (91.3) | 0.4025 | |
| IL-2 | 12 (80) | 12 (54.5) | <0.0001 | |
| CD8+ T cells response to SEB | Any Th1 | 15 (100) | 22 (100) | n/a |
| IFN-γ | 15 (100) | 22 (100) | n/a | |
| TNF-α | 13 (86.7) | 21 (95.5) | 0.3363 | |
| IL-2 | 14 (93.3) | 3 (13.6) | <0.0001 | |
In bold are indicated the significant values.
*χ2 test.
HCWs, healthcare care workers; N, Number; n/a, not available; PwMS, patients with multiple sclerosis; SEB, staphylococcal enterotoxin B.