Table 3.

Number of CD4⁺ and CD8⁺ T-cell responders among PwMS at T2 and T3

Stimulation and type of T-cell response evaluation	Cytokine produced	Responders over total N (%)
		T2 19 (100)	T3 19 (100)	P value*
Spike-specific CD4+ T cells	Any Th1	2 (10.5)	5 (26.31)	0.248
	IFN-γ	2 (10.5)	5 (26.31)	0.248
	TNF-α	2 (10.5)	0 (0)	0.479
	IL-2	0 (0)	0 (0)	n/a
Spike-specific CD8+ T cells	Any Th1	2 (10.5)	2 (10.5)	n/a
	IFN-γ	1 (5.2)	2 (10.5)	>0.9999
	TNF-α	1 (5.2)	0 (0)	>0.9999
	IL-2	0 (0)	0 (0)	n/a
CD4+ T cells response to SEB	Any Th1	17 (89.5)	19 (100)	0.479
	IFN-γ	16 (84.2)	19 (100)	0.248
	TNF-α	17 (89.5)	19 (100)	0.479
	IL-2	10 (60.1)	5 (26.3)	0.182
CD8+ T cells response to SEB	Any Th1	19 (100)	19 (100)	n/a
	IFN-γ	16 (84.2)	19 (100)	0.248
	TNF-α	11 (57.9)	18 (94.7)	0.045
	IL-2	11 (57.9)	3 (15.8)	0.026

In bold are indicated the significant values.

*McNemar’s test.

N, Number; n/a, not available; PwMS, Patients with Multiple Sclerosis; SEB, staphylococcal enterotoxin B.