Table 1.

Characteristics of included studies

	Dobrocky et al 24	Goyal et al 12	Messer et al 25	Saito et al 22	Sarraj et al 23	Seners et al 10
Countries	Switzerland, Germany	North America, Europe, Asia	Germany	Japan	USA, Spain	France
Study duration (dates)	2005–2020	2013–2017	1998–2015	2014–2016	2012–2017	2006–2018
NIHSS score	≤5	≤5	≤5	≤5	≤5	≤5
Active group	EVT±IVT	EVT±IVT	EVT±IVT	EVT±IVT	EVT±IVT	EVT±IVT
Comparator group	IVT	BMM (including IVT)	IVT	IVT	BMM (including IVT)	IVT
Outcome available in vessel occlusion sites	M2	Proximal ICA or M1 and M2	Proximal ICA or M1	Proximal ICA or M1	Proximal ICA or M1, M1, and M2	M1 and M2
ICA or M1 occlusions	0	172	26	81	122	252
M2 occlusions	164	79	0	NA	77	346
Prospective study design	No	No	No	No	No	Yes
Comparable group available	Yes	Yes	Yes	Yes	Yes	Yes
Adjustment of confounders	No	No	No	No	No	No
Documented loss of follow-up rate	No	No	No	No	No	No

BMM, best medical management; EVT, endovascular therapy; ICA, internal carotid artery; IVT, intravenous thrombolysis; M1, first segment of middle cerebral artery; M2, second segment of middle cerebral artery; NA, not available.